Functional Expression of PEPT2 in the Human Distal Lung Epithelial Cell Line NCl-H441.
作者： Mikihisa Takano , Natsumi Sugimoto , Carsten Ehrhardt , Ryoko Yumoto
DOI: 10.1007/S11095-015-1751-X
关键词:
摘要: Purpose The peptide transporter PEPT2 is expressed in alveolar type II epithelial cells. So far, however, no appropriate cell line for studying function has been known. In this study, we examined the functional expression of human distal lung NCl-H441 (H441).
springer.com
sci-hub.se 参考文章(45)
Masashi Kawami, Mioka Miyamoto, Ryoko Yumoto, Mikihisa Takano, Methotrexate influx via folate transporters into alveolar epithelial cell line A549 Drug Metabolism and Pharmacokinetics. ,vol. 30, pp. 276- 281 ,(2015) , 10.1016/J.DMPK.2015.04.005
Gen Yamano, Hisayuki Funahashi, Oichi Kawanami, Li-Xia Zhao, Nobuhiro Ban, Yoshiyuki Uchida, Toshio Morohoshi, Junichi Ogawa, Seiji Shioda, Nobuya Inagaki, ABCA3 is a lamellar body membrane protein in human lung alveolar type II cells1 FEBS Letters. ,vol. 508, pp. 221- 225 ,(2001) , 10.1016/S0014-5793(01)03056-3
Wendy S. Putnam, Lin Pan, Ken Tsutsui, Lori Takahashi, Leslie Z. Benet, Comparison of bidirectional cephalexin transport across MDCK and caco-2 cell monolayers: interactions with peptide transporters. Pharmaceutical Research. ,vol. 19, pp. 27- 33 ,(2002) , 10.1023/A:1013647114152
David A. Groneberg, Monika Nickolaus, Jochen Springer, Frank Döring, Hannelore Daniel, Axel Fischer, Localization of the Peptide Transporter PEPT2 in the Lung The American Journal of Pathology. ,vol. 158, pp. 707- 714 ,(2001) , 10.1016/S0002-9440(10)64013-8
Hidetoshi Tahara, Ryoko Yumoto, Keisuke Oda, Junya Nagai, Akira Shimamoto, Chieko Yamamoto, Keisuke Sambuichi, Mikihisa Takano, Introduction of a Single Transporter Gene ABCA3 Directs RLE-6TN to More Type II-like Alveolar Epithelial Cells 膜. ,vol. 38, pp. 246- 253 ,(2013)
Atsushi Sakamoto, Takehisa Matsumaru, Norio Yamamura, Shinobu Suzuki, Yasuo Uchida, Masanori Tachikawa, Tetsuya Terasaki, None, Drug Transporter Protein Quantification of Immortalized Human Lung Cell Lines Derived from Tracheobronchial Epithelial Cells (Calu-3 and BEAS2-B), Bronchiolar-Alveolar Cells (NCI-H292 and NCI-H441), and Alveolar Type II-like Cells (A549) by Liquid Chromatography-Tandem Mass Spectrometry. Journal of Pharmaceutical Sciences. ,vol. 104, pp. 3029- 3038 ,(2015) , 10.1002/JPS.24381
Adi F. Gazdar, James L. Mulshine, R. Ilona Linnoila, Herbert K. Oie, Yukio Kurita, Jeffrey A. Whitsett, Jean C. Clark, Peripheral Airway Cell Differentiation in Human Lung Cancer Cell Lines Cancer Research. ,vol. 50, pp. 5481- 5487 ,(1990)
Mark Gumbleton, Ghaith Al-Jayyoussi, Adam Crandon-Lewis, Danielle Francombe, Katharina Kreitmeyr, Chris J. Morris, Mathew W. Smith, Spatial expression and functionality of drug transporters in the intact lung: Objectives for further research Advanced Drug Delivery Reviews. ,vol. 63, pp. 110- 118 ,(2011) , 10.1016/J.ADDR.2010.09.008
A. Biegel, I. Knütter, B. Hartrodt, S. Gebauer, S. Theis, P. Luckner, G. Kottra, M. Rastetter, K. Zebisch, I. Thondorf, H. Daniel, K. Neubert, M. Brandsch, The renal type H+/peptide symporter PEPT2: structure-affinity relationships Amino Acids. ,vol. 31, pp. 137- 156 ,(2006) , 10.1007/S00726-006-0331-0
Winfried Neuhaus, Fabian Samwer, Steffen Kunzmann, Ralf M. Muellenbach, Michael Wirth, Christian P. Speer, Norbert Roewer, Carola Y. Förster, Lung endothelial cells strengthen, but brain endothelial cells weaken barrier properties of a human alveolar epithelium cell culture model. Differentiation. ,vol. 84, pp. 294- 304 ,(2012) , 10.1016/J.DIFF.2012.08.006