Tumour metastasis: is tissue an issue?

摘要: Single tumour cells, or multicellular aggregates, escape into blood and lymphatic vessels from a primary solid as it progresses. However, the ability of such cells to develop metastatic outgrowths is very limited, shown by poor prognostic power presence circulating in cancer patients. An explanation for this low efficiency may be temporary absence suitable microenvironment once their original tissue compartment. On basis histopathological observations, experimental studies, generally accepted prognosis histopathologically confirmed intravascular location, we propose that structural functional organisation has key role providing optimum sustained malignant dissemination. Such fixed mobile microsatellite, an micrometastasis, which locally develops overt in-transit metastasis.