Chronic effects of perchloroethylene and trichloroethylene on the gerbil brain amino acids and glutathione.

摘要: Mongolian gerbils were exposed for 12 months to trichloroethylene (TCE) 50 or 150 ppm perchloroethylene (PCE) 120 ppm. Vermis posterior of cerebellum and hippocampus used measurement high-affinity uptake release 3H-gamma-aminobutyric acid (GABA) 14C-glutamate, as well determination total free tissue amino acids glutathione. Glutathione was significantly elevated in the animals TCE. Levels not appreciably affected. After PCE exposure, months, taurine decreased even more part cerebellar vermis. Glutamine hippocampus. No other significant changes glutathione observed. exposing TCE (50 ppm) accumulation glutamate by vermis increased a dose-dependent manner, but no observed The GABA unaffected after exposure months. potassium-stimulated hippocampal slices from