作者: U. Green , J. Althoff
DOI: 10.1007/BF00411342
关键词:
摘要: Syrian golden hamsters received weekly s.c. doses of 5.0, 2.5, 1.25 or 0.63 mg/kg b.w. vinylethylnitrosamine (VEN). As dose levels increased, average survival time decreased, tumor multiplicity increased as did the total rate which was between 50% and 100%. The main target VEN effect respiratory tract where a positive dose-response relationship established for neoplastic growth.