Low Rates of Mother to Child Transmission of HIV-1 and Risk Factors for Infection in Spain
作者： Luis Manuel Prieto , María Isabel González-Tomé , Eloy Muñoz , María Fernández-Ibieta , Beatriz Soto
DOI: 10.1097/INF.0B013E31826FE968
关键词:
摘要: BACKGROUND The objective of the study was to describe temporal patterns in management HIV-1 infected women and their newborns changes over time mother-to-child transmission (MTCT) rates risk factors. METHODS A multicenter prospective observational performed Madrid, Spain, from 2000 2007. Cohort period 1 (CP1) included births 2000-2003 cohort 2 (CP2) 2004-2007. RESULTS Of 803 HIV-infected infants, 427 were CP1 376 CP2. Almost all CP2 received highly active antiretroviral therapy. More treatment for ≥16 weeks during pregnancy (72.0% vs. 84.8% CP2; P < 0.001). Overall, no differences trends mode delivery observed. proportion with vaginal deliveries who had undetectable viral loads increased 31.1% 42.7% (P = 0.02). Thirteen children (1.6%, 95% confidence interval: 0.68-2.55) by MTCT. No infection observed time. All cases MTCT occurred when not given or <16 pregnancy. CONCLUSIONS Low Lack timely provision drugs main limitation develop preventive interventions available nowadays. Nonsustained control load could be associated residual transmission.
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