Potent simian immunodeficiency virus-specific cellular immune responses in the breast milk of simian immunodeficiency virus-infected, lactating rhesus monkeys.

摘要: Breast milk transmission of HIV is a leading cause infant HIV/AIDS in the developing world. Remarkably, only small minority breastfeeding infants born to HIV-infected mothers contract via breast exposure, raising possibility that immune factors confer protection who remain uninfected. To model HIV-specific immunity milk, lactation was pharmacologically induced Mamu-A*01(+) female rhesus monkeys. The composition lymphocyte subsets hormone-induced found be similar natural milk. Hormone-induced lactating monkeys were inoculated i.v. with SIVmac251 and CD8(+) T lymphocytes specific for two immunodominant SIV epitopes, Gag p11C Tat TL8, viral load monitored peripheral blood during acute infection. 1-2 logs lower than plasma through peak set point viremia. Surprisingly, whereas kinetics SIV-specific cellular mirrored blood, magnitude response more twice as high blood. Furthermore, appearance associated reduction load, this remained higher after point. This robust viral-specific may contribute control virus replication.