Context-driven changes in L-DOPA-induced behaviours in the 6-OHDA lesioned rat.

摘要: Both contralateral rotational behaviour and dyskinetic abnormal involuntary movements (AIMs) are induced by the administration of l-DOPA in unilateral 6-OHDA lesioned rat model Parkinson's disease. Since responses can be conditioned to environmental cues we have investigated extent which drug-induced AIMS may also exteroceptive experience. In Experiment I, rats received repeated daily injections either their home cage (control) or association with a brief (20 mins) exposure rotometers (paired). To assess conditioning, all animals then two tests rotometer bowls. Following injection saline paired group both rotated more contralaterally displayed manifest AIMs, neither were exhibited control rats. Moreover, following l-DOPA, showed trend for increased AIMs compared controls. Two further studies provided longer conditioning environments counterbalanced designs. Although, using these parameters, re-exposure presence did not induce context-dependent strong context-specific component sensitised response was seen; chronic drug produced significantly stronger behavioural particular environment than This data suggests that part sensitisation responding is solely pharmacological phenomenon, but context administered. has clear implications clinical observation experimental measurement dyskinesia disease patients animal models.