Direct and indirect striatal efferent pathways are differentially influenced by low and high dyskinetic drugs: Behavioural and biochemical evidence

摘要: Abstract Clinical evidence suggests that stimulation of the D 1 rather than 2 dopamine receptor is related to development dyskinesias in Parkinson's disease (PD). We evaluated, 6-hydroxydopamine rat model PD, sensitization contralateral turning (SCT) behaviour and abnormal involuntary movements (AIMs) as behavioural parameters dyskinetic response, changes zif-268 mRNA expression striatonigral striatopallidal neurons on subchronic administration /D 3 agonist ropinirole, defined a mild drug clinic. Results were compared with previous findings repeated l -dopa treatment. Ropinirole displayed response characterized by SCT only, which contrasted presence association AIMs elicited -dopa. Zif-268 levels decreased both contrast hyper-expression selectively induced neurons. Unbalanced responsiveness striatal efferent might represent molecular correlate high potential rats; contrast, balanced output underlie low ropinirole.