Multirate delivery of multiple therapeutic agents from metal-organic frameworks
作者： Alistair C. McKinlay , Phoebe K. Allan , Catherine L. Renouf , Morven J. Duncan , Paul S. Wheatley
DOI: 10.1063/1.4903290
关键词:
摘要: The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery therapeutic agents. Here, we show that can be used to deliver multiple agents—a biologically active gas, an antibiotic drug molecule, and metal ion—simultaneously but at different rates. possibilities offered by agents with mechanisms action and, in particular, variable timescales may allow new therapy approaches. loaded MOFs are against various strains bacteria.
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sci-hub.se 参考文章(29)
C. Serre, C. Mellot-Draznieks, S. Surble, N. Audebrand, Y. Filinchuk, G. Ferey, Role of solvent-host interactions that lead to very large swelling of hybrid frameworks Science. ,vol. 315, pp. 1828- 1831 ,(2007) , 10.1126/SCIENCE.1137975
N. L. Rosi, Hydrogen Storage in Microporous Metal-Organic Frameworks Science. ,vol. 300, pp. 1127- 1129 ,(2003) , 10.1126/SCIENCE.1083440
Alistair C McKinlay, Bo Xiao, David S Wragg, Paul S Wheatley, Ian L Megson, Russell E Morris, None, Exceptional behavior over the whole adsorption-storage-delivery cycle for NO in porous metal organic frameworks. Journal of the American Chemical Society. ,vol. 130, pp. 10440- 10444 ,(2008) , 10.1021/JA801997R
Jeffrey R. Long, Omar M. Yaghi, The pervasive chemistry of metal–organic frameworks Chemical Society Reviews. ,vol. 38, pp. 1213- 1214 ,(2009) , 10.1039/B903811F
Alistair C. McKinlay, Russell E. Morris, Patricia Horcajada, Gérard Férey, Ruxandra Gref, Patrick Couvreur, Christian Serre, BioMOFs: metal-organic frameworks for biological and medical applications. Angewandte Chemie. ,vol. 49, pp. 6260- 6266 ,(2010) , 10.1002/ANIE.201000048
M. Infas H. Mohideen, Bo Xiao, Paul S. Wheatley, Alistair C. McKinlay, Yang Li, Alexandra M. Z. Slawin, David W. Aldous, Naomi F. Cessford, Tina Düren, Xuebo Zhao, Rachel Gill, K. Mark Thomas, John M. Griffin, Sharon E. Ashbrook, Russell E. Morris, Protecting group and switchable pore-discriminating adsorption properties of a hydrophilic–hydrophobic metal–organic framework Nature Chemistry. ,vol. 3, pp. 304- 310 ,(2011) , 10.1038/NCHEM.1003
Xinyi Lu, Junwei Ye, Dekui Zhang, Ruixia Xie, Raji Feyisa Bogale, Yuan Sun, Limei Zhao, Qi Zhao, Guiling Ning, Silver carboxylate metal-organic frameworks with highly antibacterial activity and biocompatibility. Journal of Inorganic Biochemistry. ,vol. 138, pp. 114- 121 ,(2014) , 10.1016/J.JINORGBIO.2014.05.005
Mohamed Eddaoudi, Jaheon Kim, Nathaniel Rosi, David Vodak, Joseph Wachter, Michael O'Keeffe, Omar M Yaghi, Systematic Design of Pore Size and Functionality in Isoreticular MOFs and Their Application in Methane Storage Science. ,vol. 295, pp. 469- 472 ,(2002) , 10.1126/SCIENCE.1067208
Bo Wang, Adrien P. Côté, Hiroyasu Furukawa, Michael O’Keeffe, Omar M. Yaghi, Colossal cages in zeolitic imidazolate frameworks as selective carbon dioxide reservoirs Nature. ,vol. 453, pp. 207- 211 ,(2008) , 10.1038/NATURE06900
Pascal D. C. Dietzel, Richard Blom, Helmer Fjellvåg, Base‐Induced Formation of Two Magnesium Metal‐Organic Framework Compounds with a Bifunctional Tetratopic Ligand European Journal of Inorganic Chemistry. ,vol. 2008, pp. 3624- 3632 ,(2008) , 10.1002/EJIC.200701284