Depression and cognitive deficits as long-term consequences of thrombotic thrombocytopenic purpura.

摘要: BACKGROUND Thrombotic thrombocytopenic purpura (TTP) is an acute life-threatening microangiopathy with a tendency of relapse characterized by consumptive thrombocytopenia, microangiopathic hemolytic anemia, and spontaneous von Willebrand factor–induced platelet clumping leading to microthrombi. The brain frequently affected microthrombi neurologic abnormalities varying severity. STUDY DESIGN AND METHODS The aim this observational cohort study was investigate the prevalence depression cognitive deficits in 104 patients having survived TTP. TTP survivors were repeatedly assessed means different standardized questionnaires evaluate (IDS-SR) mental performance (FLei). We received answers individual 55 them participated both surveys. RESULTS Seventy-one responding (68%) suffered from severity similar surveys performed 1 year apart. Furthermore, had considerably lower than controls. There no correlation between number episodes. Impairment correlated (rs = 0.779). CONCLUSION The significantly higher patients. Cognitive impairment seemed be consequence depression, almost independently