The expression of somatostatin receptors in the hippocampus of pilocarpine-induced rat epilepsy model.
作者： Sung-Eun Kwak , Ji-Eun Kim , Hui-Chul Choi , Hong-Ki Song , Yeong-In Kim
DOI: 10.1016/J.NPEP.2008.09.002
关键词:
摘要: During the course of this study, we sought examine whether expression somatostatin receptors (SSTRs) is altered in hippocampus following pilocarpine-induced status epilepticus (SE) order to understand role/function SSTRs after epileptogenic insults. SSTR1 and SSTR4 immunoreactivities were increased at 1 week SE. At 4 weeks SE, SRIF1-family (SSTR 2A, SSTR2B, SSTR5) immunoreactivity was only neuropil. Both SSTR2A 2B CA2-3 pyramidal cells. However, SSTR3 reduced CA1 cells epileptic rat due neuronal loss. In addition, SSTR5 CA2 various interneurons. SSTR2B within microglia Our findings suggest that increases neuron-glial SSTR expressions may be closely related enhanced inhibition dentate gyrus regulation reactive microgliosis a pilocarpine model temporal lobe epilepsy.
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