The Hill analysis and co-ion–driven transporter kinetics

作者: Juke S. Lolkema , Dirk-Jan Slotboom

DOI: 10.1085/JGP.201411332

关键词:

摘要: Interaction of multiple ligands with a protein or complex is widespread phenomenon that allows for cooperativity. Here, we review the use Hill equation, which commonly used to analyze binding kinetic data, kinetics ion-coupled transporters and show how mechanism transport affects coefficient. Importantly, analysis can provide exact number transported co-ions, regardless extent cooperativity in ion binding.

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