Efficacy of carvedilol in reversing hypertension induced by chronic intermittent hypoxia in rats

摘要: Animal models of chronic intermittent hypoxia (CIH) mimic the hypertension observed in patients with obstructive sleep apnoea. Antihypertensive drugs were applied to these animal address physiological mechanism but not revert established hypertension. We aimed investigate efficacy carvedilol (CVDL), an unselective beta-blocker that exhibits intrinsic anti-α1-adrenergic and antioxidant activities a rat model CIH-induced The variability CVDL enantiomers plasma concentrations was also evaluated. Wistar rats indwelling blood pressure telemeters exposed during their period 5.6 CIH cycles/h, 10.5 h/day, for 60 days. administered by gavage beginning on Day 36 continued 25 R-(+)-CVDL S-(-)-CVDL monitored HPLC. significantly increased diastolic systolic 25.7 21.6 mm Hg respectively, while no effect heart rate (HR). administration at 10, 30 50 mg/kg/day promoted significant reduction HR did affect arterial pressure. S/(R+S) ratio lower CIH. blockade sympathetic nervous system together putative pleiotropic effects alter Although induced pharmacokinetic changes R/(R+S) ratio, do appear be responsible inability reverse this particular type