Effects of third-generation β-blockers, atenolol or amlodipine on blood pressure variability and target organ damage in spontaneously hypertensive rats.

摘要: Background β-blockers are no longer considered as first-line antihypertensive drugs due to their lower cardioprotection. Method Considering the differences in pharmacological properties of β-blockers, present work compared effects third-generation - carvedilol and nebivolol with a agent amlodipine on hemodynamic parameters, including short-term blood pressure variability (BPV), ability prevent target organ damage spontaneously hypertensive rats (SHR). SHR were orally treated carvedilol, nebivolol, atenolol, or vehicle for 8 weeks. Wistar Kyoto used normotensive group. Echocardiographic evaluation, BP, BPV measurements performed. Left ventricle thoracic aorta removed histological evaluations assess expression transforming growth factor β (TGF-β), tumor necrosis factor-α (TNF-α) interleukin-6 (IL-6). Results Carvedilol, induced greater reduction carotid echocardiography parameters than atenolol rats. more effective prevention cardiac hypertrophy, aortic collagen deposit. Carvedilol but not reduced expressions fibrotic inflammatory biomarkers TGF-β, TNF-α IL-6 similar extent that amlodipine. Conclusion Chronic treatment attenuates BP BPV, reduces atenolol. Our findings suggest cardiovascular protection nonvasodilating hypertension must be translated β-blockers.