Overexpression of NEK3 is associated with poor prognosis in patients with gastric cancer.
作者： Yongfeng Cao , Jiaye Song , Jia Chen , Jinzhang Xiao , Jingyi Ni
DOI: 10.1097/MD.0000000000009630
关键词:
摘要: The NIMA-related kinase 3 (NEK3) plays an important role in cell migration, proliferation, and viability. Recently, NEK3 was reported to enhance the malignancy of breast cancer. However, its gastric cancer has not been completely characterized. In this study, we explored prognostic significance human Reverse transcription-polymerase chain reaction western blot were performed detect mRNA protein expression 6 paired fresh tissues surrounding normal tissues. levels adjacent samples 168 cases detected by immunohistochemistry, relationships between level various clinicopathological features analyzed. significantly overexpressed tissues, compared with Immunohistochemistry staining assay showed percentage high higher than that samples. overexpression correlated pT stage, pathologic TNM lymph node metastasis, poor prognosis Cox multivariate regression analyses suggested independent factor for survival patients data demonstrate is cancer, which promotes may be as a biomarker potential therapeutic target
sci-hub.se 参考文章(29)
Stephen B. Edge, Carolyn C. Compton, The American Joint Committee on Cancer: the 7th Edition of the AJCC Cancer Staging Manual and the Future of TNM Annals of Surgical Oncology. ,vol. 17, pp. 1471- 1474 ,(2010) , 10.1245/S10434-010-0985-4
XiangBin Xing, Yong-Bo Tang, Gang Yuan, YongFei Wang, JinHui Wang, Yang Yang, MinHu Chen, The prognostic value of E-cadherin in gastric cancer: a meta-analysis. International Journal of Cancer. ,vol. 132, pp. 2589- 2596 ,(2013) , 10.1002/IJC.27947
M. Kimura, Y. Okano, Molecular cloning and characterization of the human NIMA-related protein kinase 3 gene (NEK3). Cytogenetic and Genome Research. ,vol. 95, pp. 177- 182 ,(2001) , 10.1159/000059342
Levent Bekir Beder, Mehmet Gunduz, Mamoru Ouchida, Kunihiro Fukushima, Esra Gunduz, Sachio Ito, Akiko Sakai, Noriyuki Nagai, Kazunori Nishizaki, Kenji Shimizu, Genome-Wide Analyses on Loss of Heterozygosity in Head and Neck Squamous Cell Carcinomas Laboratory Investigation. ,vol. 83, pp. 99- 105 ,(2003) , 10.1097/01.LAB.0000047489.26246.E1
S Rogers, R Wells, M Rechsteiner, Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis Science. ,vol. 234, pp. 364- 368 ,(1986) , 10.1126/SCIENCE.2876518
A. M. Fry, L. O'Regan, S. R. Sabir, R. Bayliss, Cell cycle regulation by the NEK family of protein kinases Journal of Cell Science. ,vol. 125, pp. 4423- 4433 ,(2012) , 10.1242/JCS.111195
J. Chang, R. H. Baloh, J. Milbrandt, The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons. Journal of Cell Science. ,vol. 122, pp. 2274- 2282 ,(2009) , 10.1242/JCS.048975
Tsutomu Chiba, Hiroyuki Marusawa, Toshikazu Ushijima, Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation. Gastroenterology. ,vol. 143, pp. 550- 563 ,(2012) , 10.1053/J.GASTRO.2012.07.009
Matteo Malvezzi, Martina Bonifazi, Paola Bertuccio, Fabio Levi, Carlo La Vecchia, Adriano Decarli, Eva Negri, An age-period-cohort analysis of gastric cancer mortality from 1950 to 2007 in Europe. Annals of Epidemiology. ,vol. 20, pp. 898- 905 ,(2010) , 10.1016/J.ANNEPIDEM.2010.08.013
Baoying Hu, Dawei Jiang, Yuyan Chen, Lixian Wei, Shusen Zhang, Fengbo Zhao, Runzhou Ni, Cuihua Lu, Chunhua Wan, High CHMP4B expression is associated with accelerated cell proliferation and resistance to doxorubicin in hepatocellular carcinoma. Tumor Biology. ,vol. 36, pp. 2569- 2581 ,(2015) , 10.1007/S13277-014-2873-1