Regulation of serine protease activity by aluminum: implications for Alzheimer disease.

摘要: Abstract The brain of Alzheimer disease patients contains plaques that are diagnostic for the disease. The also contain beta-amyloid peptide, alpha 1-antichymotrypsin, and element aluminum. We present indirect evidence can relate all three components to each other in such a way as suggest their involvement etiology peptide is derived by proteolytic processing from precursor proteins some these domain highly homologous bovine pancreatic trypsin inhibitor. Bovine inhibitor inhibits alpha-chymotrypsin we show aluminum affects both activity inhibition this enzyme. At pH 6.5, presence aluminum, enzyme doubled, only 1% effective absence metal ion. BX-9, protease prepared protein amyloid plaques, reduced aluminum; so too 1-antichymotrypsin but lesser degree. In brain, propose may accelerate suppression domain. Thus, accumulate initiate plaque formation.