Apatinib has anti-tumor effects and induces autophagy in colon cancer cells.
作者： Yu Honggang , Ding Qianshan , Wang Zhen , He Ke , Wu Lu
关键词:
摘要: Objective(s): Apatinib recently has been used to treat patients with gastric cancer, but the function of apatinib in colon cancer remains unclear. This study was conducted investigate impacts on biological and its potential mechanism cells vitro. Materials Methods:The effect were detected by assessing cell viability, migration invasion capabilities. Apoptosis cycle distribution analyzed flow cytometry. The investigated via autophagy related proteins pathways Results: proliferation, inhibited when they treated different concentration (20, 40 μM). When HCT116 SW480 at 20 μM, apoptosis percentage 3.7% 5.8% respectively. As drug increased 40μΜ, 11.9% 13.5%. Meanwhile, also altered. Furthermore, expression AKT-mTOR signaling pathway LC3-Ⅱ. Conclusion: can significantly inhibit malignant phenotype cells, it involved regulation autophagy.
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