Prognostic factors in advanced breast cancer: Race and receptor status are significant after development of metastasis

摘要: Prognostic factors are well established in early-stage breast cancer (BC), but less well-defined advanced disease. We analyzed 323 BC patients who had distant relapse during follow-up from 1997 to 2010 determine the significant clinicopathologic predicting survival outcomes. By univariate analysis, race, tumor grade, estrogen and progesterone receptors (ER/PR) HER2 status were significantly associated with overall (OS) post-metastasis (PMS). Applying a Cox regression model revealed that all these remained for PMS, while grade independent OS. Tumor was only factor metastasis-free by multivariate analyses. Our findings demonstrated being Caucasian, hormonal receptor positive (HR+) (HER2+) decreased hazard of death HR+/HER2+ tumors superior outcomes those HR+/HER2- Further, PR held prognostic value over ER, thus reflecting biologic mechanism importance functional ER pathway heterogeneity response endocrine therapy. These observations indicate patients' genetic makeup intrinsic nature principally govern progression prognosticate long-term