Serum folate receptor alpha, mesothelin and megakaryocyte potentiating factor in ovarian cancer: association to disease stage and grade and comparison to CA125 and HE4
作者： Daniel J O’Shannessy , Elizabeth B Somers , Leslie M Palmer , Robert P Thiel , Pankaj Oberoi
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摘要: Evaluate and compare the utility of serum folate receptor alpha (FRA) megakaryocyte potentiating factor (MPF) determinations relative to CA125, mesothelin (MSLN) HE4 for diagnosis epithelial ovarian cancer (EOC). Electrochemiluminescent assays were developed FRA, MSLN MPF used assess levels these biomarkers in 258 samples from patients. Commercial CA125 run on a subset 176 representing serous histology. Data was analyzed by histotype, stage grade disease. A comparison serum, plasma urine also performed 57 Serum shown be highly correlated between two matrices. Correlations all pairs markers 318 calculated demonstrated highest correlation MPF, lowest FRA MPF. showed dependence both multi-marker logistic regression model resulting an AUC=0.91 cancer, significant improvement over AUC any individual markers, including (AUC=0.84). has potential as biomarker stand-alone marker combination with other known EOC. The lack various present study suggests that panel can aid detection and/or monitoring this
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