Brain-Derived Neurotrophic Factor (BDNF) in Traumatic Brain Injury-Related Mortality: Interrelationships Between Genetics and Acute Systemic and Central Nervous System BDNF Profiles.
作者： Michelle D. Failla , Yvette P. Conley , Amy K. Wagner
关键词:
摘要: Background. Older adults have higher mortality rates after severe traumatic brain injury (TBI) compared to younger adults. Brain-derived neurotrophic factor (BDNF) signaling is altered in aging and important TBI given its role neuronal survival/plasticity autonomic function. Following experimental TBI, acute BDNF administration has not been efficacious. Clinically, genetic variation (reduced alleles: rs6265, Met-carriers; rs7124442, C-carriers) can be protective against mortality. Postacutely, these genotypes carry lower risk older greater among Objective. Investigate levels mortality/outcome following the context of age risk. Methods. Cerebrospinal fluid (CSF) serum were assessed prospectively during first week (n = 203) controls 10). Age, genotype, as predictors. Results. CSF l...
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