Decreased Brain-Derived Neurotrophic Factor Serum Concentrations in Chronic Post-Stroke Subjects

摘要: Background Brain-derived neurotrophic factor (BDNF) plays a critical role in sensorimotor recovery after stroke. However, few studies have assessed the circulating BDNF levels post-stroke humans to understand its changes. This study was conducted measure serum concentrations subjects with chronic hemiparesis, as well correlate age, time, total score of Stroke Specific Quality Life Scale (SS-QOL), mobility subscale score, and motor function SS-QOL. Methods Seventeen matched by age gender healthy controls took part study. Personal data (age, hemiparesis side, time) were collected, physical examination (weight, height, body mass index) SS-QOL assessment carried out. On same day, initial evaluation, venous blood samples collected from subjects. The measured blindly enzyme-linked immunosorbent assay. Results Subjects presented decrease compared ( P  > .05). are related structural functional stroke; thus, this reduction is important rehabilitation process more clearly. needed considering genetic variations other tools assess impairment independence. Conclusion Chronic concentrations, without correlation quality life.