Pharmacological evidence for the activation of Ca2+-activated K+ channels by meloxicam in the formalin test.

摘要: The possible participation of K+ channels in the antinociceptive action meloxicam was assessed 1% formalin test. Local peripheral administration produced a dose-dependent antinociception only during second phase channel blockers alone did not modify formalin-induced nociceptive behavior. However, local pretreatment paw with charybdotoxin and apamin (large- small-conductance Ca2+-activated inhibitors, respectively), 4-aminopyridine tetraethylammonium (non-selective voltage-dependent inhibitors), but glibenclamide or tolbutamide (ATP-sensitive dose-dependently prevented meloxicam-induced antinociception. It is concluded that could open large- channels, ATP-sensitive order to produce its effect also suggested, since non-selective inhibitors were used data await further confirmation.