Model structures and action of interleukin 1 and its antagonist

摘要: A comparison has been made between the homology and hydrophobicity profiles of six interleukin amino acid sequences that human 1β (IL-1β) for which a crystal structure exists. The resulting sequence alignment was used to build model structures three IL-1α, two IL-1β an receptor antagonist. Analysis these demonstrates molecule strong electric dipole is generated by topological position acids in sequence. Electrostatic surface calculations implicate particular residues (Lys145) as being fundamental activity this supports site-directed mutation evidence residue required