2,5-Diketopiperazines, new chiral auxiliaries for asymmetric Diels-Alder reactions
作者： Thuy X.H. Le , Jacqueline C. Bussolari , William V. Murray
DOI: 10.1016/S0040-4039(97)00769-7
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摘要: Abstract Diketopiperazines have been utilized as chiral auxiliaries for asymetric Diels-Alder reactions. Cyclo-S-phenylalanyl-R-proline (2) was found to be the most promising of these and afforded adducts in high chemical yield (78–95%), with endo selectivities generally greater than 9:1. The diastereoselectivities observed were comparable best previously published values.
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