Highly Enantioselective Alkynylation of α-Keto Ester: An Efficient Method for Constructing a Chiral Tertiary Carbon Center
作者： Biao Jiang , Zili Chen , Xiaoxia Tang
DOI: 10.1021/OL026544I
关键词:
摘要: The asymmetric addition of terminal alkynes to α-keto ester was carried out using a catalytic amount (1S,2S)-3-(tert-butyldimethylsilyloxyl)-2-N,N-(dimethylamino)-1-(p-nitrophenyl)-propane-1-ol in the presence Zn(OTf)2 give corresponding tertiary propargylic alcohols high yields with up 94% ee. N-Methylephedrine and Zn(OSO2CHF2)2 were also examined this reaction.
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