A membrane motor model for the fast motility of the outer hair cell

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DOI: 10.1121/1.410094

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摘要: A model is presented for describing the membrane potential‐dependent motility of outer hair cell. This assumes that due to conformational changes motor molecules in plasma membrane. Two kinds experimental observations, elasticity cell and stretch dependence molecule, are important characterize this by model. The molecule can be described a two‐state which has electrical mechanical components free energy. component charge transferred across change area two states. It shown elastic element connected series. Thus apparent strain represented sum true molecules. predicts amplitude movement force produced motility. under isometric condition about 0.1 nN/mV, agreement with values estimated from vivo conditions. effect an load attached also discussed.

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