The Outer Hair Cell: A Mechanoelectrical and Electromechanical Sensor/Actuator

摘要: The outer hair cell (OHC) is unique to mammals and required perceive discriminate high frequency sounds (> 10 kHz). This sensory has the remarkable motor ability convert sound induced receptor potentials into mechanical energy (electromotility). Although mechanism of electromotility remained elusive, a systematic review its characteristics places many constraints on possible models. A sensor-motor resides in cell’s lateral plasma membrane, outermost layer an elegant trilaminate wall. passive biophysical properties this wall contribute robustness electromotile response. Analysis modeling OHC important step understanding putative role as cochlear amplifier. requires that OHCs are both sensors actuators making self-assembling micro-electro-mechanical system. Electromotility been observed membranes other types, suggesting universal mechanism. will focus electromotility.