Cyanide Bridged Platinum-Iron Complexes as Cisplatin Prodrug Systems: Design and Computational Study.
作者： Ariela W. Kaspi‐Kaneti , Srijana Bhandari , Alexander Schubert , Songping D. Huang , Barry D. Dunietz
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摘要: The potential role of cyanide-bridged platinum-iron complexes as an anti-cancer Pt(IV) prodrug is studied. We present design principles a dual-function that can upon reduction dissociate and release concurrently six cisplatin units ferricyanide anion per unit. molecule unique complex hepta metal centers consisting core with each bonded to the Fe(III) through cyano ligand. functionality addressed density functional theory (DFT) calculations.
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