Metformin use is associated with a decreased incidence of colorectal adenomas in diabetic patients with previous colorectal cancer

摘要: Abstract Background Metformin use has been associated with decreased cancer risk and mortality. However, the effects of metformin on development colorectal adenomas, precursors cancers, are not defined. Aims This study aimed to evaluate potential effect incidence adenomas in diabetic patients previous cancer. Methods Among 488 consecutive who underwent colonoscopic surveillance after curative resection between 1998 2008, 240 were enrolled this compared two groups: 114 taking 126 metformin. Patient demographics, clinical characteristics, adenoma rate analysed. Results After a median follow-up 58 months, total 33 (28.9%) exhibited adenomatous polyps among used metformin, (46.0%) did (odds ratio = 0.48, 95% confidence interval = 0.280–0.816, P  = 0.008). adjustment for clinically relevant factors, was found be ratio = 0.27, interval = 0.100–0.758,  = 0.012) is lower adenoma.