Targeting JAK kinase in solid tumors: emerging opportunities and challenges.

作者: M Buchert , C J Burns , M Ernst

DOI: 10.1038/ONC.2015.150

关键词:

摘要: … a tumor cell intrinsic requirement for the JAK/STAT3 pathway for the most common forms of sporadic CRC. These arise in >80% of cases from aberrant activation of the WNT/β-catenin …

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