Improved skin oxygenation after benzyl nicotinate application in different carriers as measured by EPR oximetry in vivo

摘要: The development of formulations, which increase skin oxygenation and methods for measuring oxygen levels in are important dealing with processes affected by the level oxygen, e.g., rate healing efficiency radiation oncology. In this study we have investigated role carriers on efficacy benzyl nicotinate (BN) action after dermal application different formulations EPR oximetry vivo. time course pO2 rubefacient is followed directly first time. results obtained proved applicability vivo as a sensitive method small alterations can be detected. We found that type vehicle significantly influences when BN starts to act, duration its action, maximal pO2. ranking was: lipid nanoparticles hydrophilic gel>liposomes gel>hydrophilic gel>hydrophobic ointment>hydrophobic cream. Primarily semi-solid determines lag-time but influenced decisively particulate carrier systems. effectiveness was dose dependent. 2.5% w/w concentration appears most appropriate therapeutic application. After repeated successive base line noticed.