Evaluation of liposomes as drug carriers into the skin by one-dimensional EPR imaging
作者： V. Gabrijelčič , M. Šentjurc , J. Kristl
DOI: 10.1016/0378-5173(90)90032-Y
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摘要: Abstract One-dimensional electron paramagnetic resonance imaging (1D-EPRI) was used to evaluate quantitatively the influence of size and composition liposomes on translational mobility liposome-entrapped charged hydrophilic molecules (ASL) into skin. It found that only ASL entrapped in small unilamellar vesicles (SUV) or reverse-phase evaporation (REV) from ‘fluid’ phospholipids (egg soya lecithin phosphatidylserine) can diffuse, while free multilamellar (MLV) REV ‘solid’ (dipalmitoyl lecithin/dipalmitoylglycerol) do not penetrate. The 1D-EPRI method be useful for study diffusion drugs
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