Toxicity and drug exposure in a quadruple drug regimen in HIV-1 infected patients participating in the ADAM study.

作者: Monique H.E. Reijers , Hugo M. Weigel , Augustinus A.M. Hart , Reinier W. Ten Kate , Jan Willem Mulder

DOI: 10.1097/00002030-200001070-00007

关键词:

摘要: ObjectiveTo study the relationship between toxicity and exposure to nelfinavir saquinavir as part of a quadruple drug regimen.DesignThe ADAM is randomized investigate feasibility induction-maintenance therapy in HIV-1 infection.MethodsHIV-1-infected patients with no p

参考文章(25)
Patrizio Lorenzi, Sabine Yerly, Karmine Abderrakim, Marc Fathi, Olivier T. Rutschmann, Jan von Overbeck, Dominique Leduc, Luc Perrin, Bernard Hirschel, Toxicity, efficacy, plasma drug concentrations and protease mutations in patients with advanced HIV infection treated with ritonavir plus saquinavir. Swiss HIV Cohort Study AIDS. ,vol. 11, pp. 95- 99 ,(1997) , 10.1097/00002030-199712000-00002
Peter Reiss, Stephano Vella, David Cooper, Joep Lange, Marianne Harris, Mark A. Wainberg, Patrick Robinson, Maureen Myers, David Hall, Janet M. Raboud, Julio S.G. Montaner, Brian Conway, Sandra Rae, Suppression of plasma viral load below 20 copies/ml is required to achieve a long-term response to therapy. AIDS. ,vol. 12, pp. 1619- 1624 ,(1998) , 10.1097/00002030-199813000-00008
Scott L. Zeger, Kung-Yee Liang, Longitudinal data analysis for discrete and continuous outcomes. Biometrics. ,vol. 42, pp. 121- 130 ,(1986) , 10.2307/2531248
Yves Mouton, Serge Alfandari, Michel Valette, François Cartier, Pierre Dellamonica, Guy Humbert, Jean Marie Lang, Patrice Massip, Denis Mechali, Pascale Leclercq, Jacques Modai, Henri Portier, Impact of protease inhibitors on AIDS-defining events and hospitalizations in 10 French AIDS reference centres. Fédération National des Centres de Lutte contre le SIDA. AIDS. ,vol. 11, ,(1997) , 10.1097/00002030-199712000-00003
Enrica Pazè, 12th World AIDS Conference The Lancet. ,vol. 352, pp. 1072- 1072 ,(1998) , 10.1016/S0140-6736(05)60120-1
Stephanie A. Rhone, Robert S. Hogg, Benita Yip, Chris Sherlock, Brian Conway, Martin T. Schechter, Michael V. OʼShaughnessy, Julio S.G. Montaner, The antiviral effect of ritonavir and saquinavir in combination amongst HIV-infected adults : results from a community-based study AIDS. ,vol. 12, pp. 619- 624 ,(1998) , 10.1097/00002030-199806000-00011
Ronald T Mitsuyasu, Paul R Skolnik, Stuart R Cohen, Brian Conway, M John Gill, Peter C Jensen, Joseph J Pulvirenti, Leonard N Slater, Robert T Schooley, Melanie A Thompson, Ramon A Torres, Christos M Tsoukas, NV15355 Study Team, None, Activity of the soft gelatin formulation of saquinavir in combination therapy in antiretroviral-naive patients AIDS. ,vol. 12, ,(1998) , 10.1097/00002030-199811000-00001
Richard M.W. Hoetelmans, Marjolijn van Essenberg, Pieter L. Meenhorst, Jan W. Mulder, Jos H. Beijnen, Determination of saquinavir in human plasma, saliva, and cerebrospinal fluid by ion-pair high-performance liquid chromatography with ultraviolet detection Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 698, pp. 235- 241 ,(1997) , 10.1016/S0378-4347(97)00268-5
Dale J. Kempf, Richard A. Rode, Yi Xu, Eugene Sun, Margo E. Heath-Chiozzi, Joaquin Valdes, Anthony J. Japour, Sven Danner, Charles Boucher, Akhteruzzaman Molla, John M. Leonard, The duration of viral suppression during protease inhibitor therapy for HIV-1 infection is predicted by plasma HIV-1 RNA at the nadir AIDS. ,vol. 12, pp. 9- 14 ,(1998) , 10.1097/00002030-199805000-00001
Concepta Merry, Michael G. Barry, Fiona Mulcahy, Kathryn L. Halifax, David J. Back, Saquinavir pharmacokinetics alone and in combination with nelfinavir in HIV-infected patients AIDS. ,vol. 11, pp. F117- F120 ,(1997) , 10.1097/00002030-199715000-00001