A phase 2 trial of intravenous and intraperitoneal paclitaxel combined with S-1 for treatment of gastric cancer with macroscopic peritoneal metastasis.
作者： Hironori Yamaguchi , Joji Kitayama , Hironori Ishigami , Shigenobu Emoto , Hiroharu Yamashita
DOI: 10.1002/CNCR.28204
关键词:
摘要: BACKGROUND The prognosis of patients with gastric cancer peritoneal metastasis is extremely poor. This phase 2 study evaluated the benefits and tolerability weekly intravenous intraperitoneal paclitaxel (PTX) treatment combined oral S-1 in who had macroscopic metastasis. METHODS Patients primary tumors were enrolled. PTX was administered intravenously at 50 mg/m2 intraperitoneally 20 on days 1 8, respectively. 80 per day for 14 consecutive days, followed by 7 rest. The endpoint 1-year overall survival (OS) rate. secondary endpoints response rate, efficacy against malignant ascites, safety. RESULTS Thirty-five median number courses 11 (range, 2-35). OS rate 77.1% (95% confidence interval, 60.5-88.1). 71% target lesions. Malignant ascites disappeared or decreased 15 22 (68%) patients. frequent grade 3/4 toxic effects neutropenia (34%), leukopenia (23%), anemia (9%). CONCLUSIONS Combination chemotherapy consisting well-tolerated effective have metastasis. Cancer 2013;119:3354–8. © 2013 American Society.
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