Oral-Contraceptive-Induced Benign Liver Tumors—The Magnitude of the Problem

摘要: In order to provide a rough estimate of the annual number benign liver tumors induced by oral contraceptives (OCs) in U.S. resources Commission on Professional and Hospital Activities (CPHA) Ann Arbor Michigan were used. CPHA obtains discharge diagnosis information about 40% patients discharged from hospitals. From this data base cooperation with IMS America Limited has constructed sample 1% all short-term general hospital discharges Using identified women younger than age 48 who during period 1970-76 tumor or biliary passages. The provided allowed for telephone contact physician attending obtain histologic OC use before diagnosis. There 7 cases whom was consistent type reported be associated use: hamartoma 3; adenoma focal nodular hyperplasia 1. Positive evidence recorded 3 these cases. remaining 4 it impossible use. For purpose estimating OCs been assumed that none 2 whose exact unknown related is estimated there 700 100/year. Vana et al. 1977 140 - an estimation similar obtained data. Both estimates sufficient conclude likely hundreds rather thousands.