A Highly Efficient Single-Chain Metal-Organic Nanoparticle Catalyst for Alkyne-Azide "Click" Reactions in Water and in Cells.

摘要: We show that copper-containing metal–organic nanoparticles (MONPs) are readily synthesized via Cu(II)-mediated intramolecular cross-linking of aspartate-containing polyolefins in water. In situ reduction with sodium ascorbate yields Cu(I)-containing MONPs serve as highly efficient supramolecular catalysts for alkyne–azide “click chemistry” reactions, yielding the desired 1,4-adducts at low parts per million catalyst levels. The have toxicity and metal loadings, making them convenient, green “click” reactions Cu-MONPs enter cells perform efficient, biocompatible click chemistry, thus acting intracellular nanoscale molecular synthesizers.