Use of in situ-generated dimethyldioxirane for inactivation of biological agents.

摘要: Dimethyldioxirane (DMDO), generated in situ by adding acetone to an aqueous solution containing potassium peroxymonosulfate (Oxone) at neutral pH, was investigated for inactivation of biological warfare agent simulants. The DMDO inactivated bacterial spores, fungal vegetative cells, viruses, and protein 7 orders magnitude less than 10 min. kill rates were more pronounced when compared buffered Oxone alone. Conditions the use as a decontaminant optimized evaluating effects age temperature on open systems. effectiveness that current solutions such DS2 (used U.S. military), bleach, hydrogen peroxide shown be superior achieving 7-log Bacillus atrophaeus, anthracis spore simulant. results demonstrate potential fill need noncorrosive, nontoxic, environmentally safe decontaminant.