PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes.
作者： Patricia D. Pelton , Lubing Zhou , Keith T. Demarest , Thomas P. Burris
关键词:
摘要: The peroxisome-proliferator activated receptor gamma (PPARgamma), a member of the nuclear superfamily ligand transcription factors, plays key role in anti-diabetic actions thiazolidinediones (TZDs). PPARgamma induces expression many genes involved lipid anabolism, including adipocyte fatty acid binding protein (aP2), and is regulator differentiation. also expressed hematopoietic cells up-regulated monocytes/macrophages. Activation may play induction differentiation macrophages to foam that are associated with atherosclerotic lesions. We report both natural synthetic agonists induce time- dose-dependent increases aP2 mRNA primary human monocytes monocytic cell line, THP-1. These data suggest activation monocyte function analogous its well-characterized adipocytes.
elsevier.com
sci-hub.se 参考文章(20)
G. Greene, L. Hsieh, B. Blumberg, H. F. Yi, O. W. McBride, K. Kronquist, M. E. Greene, K. Kwan, S. D. Nimer, Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping. Gene Expression. ,vol. 4, pp. 281- 299 ,(1995)
R.T. White, D Damm, N Hancock, B.S. Rosen, B.B. Lowell, P Usher, J.S. Flier, B.M. Spiegelman, Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue Journal of Biological Chemistry. ,vol. 267, pp. 9210- 9213 ,(1992) , 10.1016/S0021-9258(19)50409-4
Jin Jiang, Gary Struhl, Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb Nature. ,vol. 391, pp. 493- 496 ,(1998) , 10.1038/35154
Giulia Chinetti, Sabine Griglio, Micheline Antonucci, Inés Pineda Torra, Philippe Delerive, Zouher Majd, Jean-Charles Fruchart, John Chapman, Jamila Najib, Bart Staels, Activation of Proliferator-activated Receptors α and γ Induces Apoptosis of Human Monocyte-derived Macrophages Journal of Biological Chemistry. ,vol. 273, pp. 25573- 25580 ,(1998) , 10.1074/JBC.273.40.25573
Mercedes Ricote, Andrew C. Li, Timothy M. Willson, Carolyn J. Kelly, Christopher K. Glass, The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation Nature. ,vol. 391, pp. 79- 82 ,(1998) , 10.1038/34178
Chengyu Jiang, Adrian T. Ting, Brian Seed, PPAR-γ agonists inhibit production of monocyte inflammatory cytokines Nature. ,vol. 391, pp. 82- 86 ,(1998) , 10.1038/34184
C. E. Mogensen, The glomerular permeability determined by dextran clearance using Sephadex gel filtration. Scandinavian Journal of Clinical & Laboratory Investigation. ,vol. 21, pp. 77- 82 ,(1968) , 10.3109/00365516809076979
Peter Tontonoz, Laszlo Nagy, Jacqueline G.A Alvarez, Vilmos A Thomazy, Ronald M Evans, PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL Cell. ,vol. 93, pp. 241- 252 ,(1998) , 10.1016/S0092-8674(00)81575-5
Barry M. Forman, Peter Tontonoz, Jasmine Chen, Regina P. Brun, Bruce M. Spiegelman, Ronald M. Evans, 15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ Cell. ,vol. 83, pp. 803- 812 ,(1995) , 10.1016/0092-8674(95)90193-0
M. Ricote, J. Huang, L. Fajas, A. Li, J. Welch, J. Najib, J. L. Witztum, J. Auwerx, W. Palinski, C. K. Glass, Expression of the peroxisome proliferator-activated receptor γ (PPARγ) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 7614- 7619 ,(1998) , 10.1073/PNAS.95.13.7614