IgG4-related Sclerosing Mastitis: Description of a New Member of the IgG4-related Sclerosing Diseases

摘要: Immunoglobulin G (IgG)4-related sclerosing disease is a recently described syndrome characterized by mass-forming lesions in various organs due to dense lymphoplasmacytic infiltrates and stromal sclerosis, elevated serum IgG4 titer, increased tissue plasma cells, favorable clinical outcome. We describe 4 patients with IgG4-related mastitis, which represents new member of this family diseases. All were female mean age 47.5 years, presenting painless masses 1 or both breasts. One patient had concurrent lymphadenopathy, another eyelid swelling undetermined cause. The titer was tested patient, circulating autoantibodies found 3 patients. well no recurrence after excision biopsy the mass. Histologically, breast featured infiltrates, prominent sclerosis loss lobules. Phlebitis present case. cells ranged from 272 495 per high-power field, constituting 49% 85% all IgG cells. scarce 9 cases lymphocytic mastitis 6 7 granulomatous studied as controls. In summary, appears be distinctive form sometimes accompanied other components disease, shows