The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum).

摘要: Summary This paper describes the genome sequence of M. thermoacetica (f. Clostridium thermoaceticum), which is model acetogenic bacterium that has been widely used for elucidating WoodLjungdahl pathway CO and CO2 fixation. pathway, also known as reductive acetyl-CoA allows (often called homoacetogenic) bacteria to convert glucose stoichiometrically into three mol acetate grow autotrophically using H2 electron donors an acceptor. Methanogenic archaea use this in reverse by converting methane CO2. Acetogenic couple Wood-Ljungdahl a variety other pathways allow metabolism wide carbon sources (sugars, carboxylic acids, alcohols, aromatic compounds) acceptors (CO2, nitrate, nitrite, thiosulfate, dimethylsulfoxide, carboxyl groups). The consists single circular 2628784 bp chromosome encoding 2615 open reading frames, includes 2523 predicted protein-encoding genes. Of these, 1834 genes (70.13%) have assigned tentative functions, 665 (25.43%) matched unknown function, remaining 24 (0.92%) had no database match. Two thousand hundred eighty-four (91.17%) ORFs can be grouped ortholog clusters. first provides important information related how acetogens engage their extreme metabolic diversity switching among different substrates donors/acceptors they conserve energy anaerobic respiration. Our analysis indicates key genetic trait homoacetogenesis core acs gene cluster pathway.