Cytogenetic effect of technical glyphosate on cultivated bovine peripheral lymphocytes
作者： Katarína Šiviková , Ján Dianovský
DOI: 10.1016/J.IJHEH.2005.07.005
关键词:
摘要: Abstract A technical herbicide containing isopropyl amine salt of glyphosate was tested for induction chromosome aberrations (CA) and sister chromatid exchanges (SCE) in cultured bovine peripheral lymphocytes. Cultures were exposed to a formulation at concentrations ranging from 28 1120 μmol/l without with metabolic activation. No clastogenic effect the found. Its genotoxic confirmed SCE assay after 24 h incubation. statistically significant elevation observed each donors application product doses 56 1120 μmol/l. The highest (560 1120 μmol/l) also caused reduction mitotic proliferation indices. In 2 h-assay activation frequency only cultures treated agent concentration 140 μmol/l.
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