Wood smoke particles from different combustion phases induce similar pro-inflammatory effects in a co-culture of monocyte and pneumocyte cell lines

摘要: Background: Exposure to particulate matter (PM) has been linked several adverse cardiopulmonary effects, probably via biological mechanisms involving inflammation. The pro-inflammatory potential of PM depends on the particles’ physical and chemical characteristics, which again depend emitting source. Wood combustion is a major source ambient air pollution in Northern countries during winter season. overall aim this study was therefore investigate cellular responses wood smoke particles (WSPs) collected from different phases cycle, at temperatures. Results: WSPs cycle induced very similar effects mediator release, cytotoxicity cell number, whereas medium-temperature were more cytotoxic than high-temperature incomplete combustion. Furthermore, comparisons by native with corresponding organic extracts washed revealed that fraction most important determinant for WSP-induced effects. However, could generally not be content measured polycyclic aromatic hydrocarbons (PAHs), suggesting also other compounds involved. Conclusion: toxicity seems large extent determined stove type conditions, rather phase cycle. Notably, strongly fraction, it associated components commonly unsubstituted PAHs.