Modeling, signaling and cytoskeleton dynamics: integrated modeling-experimental frameworks in cell migration
作者： Meng Sun , Muhammad H. Zaman
DOI: 10.1002/WSBM.1365
关键词:
摘要: Cell migration is a complex and multistep process involved in homeostasis maintenance, morphogenesis, disease development, such as cancer metastasis. Modeling cell the relevant cytoskeleton dynamics have profound implications for studying fundamental development diagnosis. This review focuses on some recent models of both migration-related dynamics, addressing issues difference between amoeboid mesenchymal modes, single-cell collective migration. The also highlights computational integration among variable external cues, especially biochemical mechanical signaling that affects Finally, we aim to identify gaps our current knowledge potential strategies develop integrated modeling-experimental frameworks multiscale behavior integrating gene expression, signaling, mechanics, multicellular dynamics. WIREs Syst Biol Med 2017, 9:e1365. doi: 10.1002/wsbm.1365 For further resources related this article, please visit website.
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