Regulated Expression of the Bone-Specific Osteocalcin Gene by Vitamins and Hormones

摘要: Publisher Summary This chapter describes the regulated expression of bone-specific osteocalcin gene by vitamins and hormones. Expression synthesized protein is developmentally during osteoblast differentiation responsive to numerous physiologic mediators bone formation resorption. Osteocalcin a major noncollagenous product differentiated osteoblast, which forms extracellular matrix (ECM). As ECM mineralizes, enveloping osteoblasts, transform into osteocytes, retained. Gla content may influence structural properties binding hydroxyapatite component bone. Human incompletely γ-carboxylated in adults compared other species, human contains one-third level present rat or bovine The possibility that participate turnover resorption was addressed series vivo vitro studies, using several model systems examined effects directly cultured cells substrates.