Viruses and Autoimmune Diabetes: A History

作者: R. David G. Leslie , Lily Ho-Le , Huriya Beyan

DOI: 10.1007/978-1-4614-4051-2_2

关键词:

摘要: Autoimmune diseases are the third leading cause of morbidity and mortality in developed world, only surpassed by cancer heart disease. The identification an association between autoimmune disease, type 1 diabetes, certain genes transformed our understanding this disease other related diseases, including thyroid multiple sclerosis. But non-genetic factors also important, chapter tracks these how that knowledge has flowered recent years. In last decade, attention focused on possibility immunomodulation as a secondary or tertiary form prevention diabetes. decline interest destructive immune change potential target therapy switched focus away from autoimmunity back to non-genetic, specifically environmental, events. Given environmental have, indeed, been implicated aetiology prospect is held intervention avoid limit exposure such might eventually reduce incidence of, even eliminate,

参考文章(24)
A. F. Michael, F. Goetz, D. E. R. Sutherland, R. K. Sibley, Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases. Laboratory Investigation. ,vol. 53, pp. 132- 144 ,(1985)
J Nerup, P Platz, O.Ortved Andersen, M Christy, J Lyngsøe, J.E Poulsen, L.P Ryder, M Thomsen, L.Staub Nielsen, A Svejgaard, HL-A antigens and diabetes mellitus. The Lancet. ,vol. 304, pp. 864- 866 ,(1974) , 10.1016/S0140-6736(74)91201-X
M. J. Redondo, L. Yu, M. Hawa, T. Mackenzie, D. A. Pyke, G. S. Eisenbarth, R. D. G. Leslie, Heterogeneity of type I diabetes: analysis of monozygotic twins in Great Britain and the United States. Diabetologia. ,vol. 44, pp. 354- 362 ,(2001) , 10.1007/S001250051626
David Leslie, Peter Lipsky, Abner Louis Notkins, Autoantibodies as predictors of disease Journal of Clinical Investigation. ,vol. 108, pp. 1417- 1422 ,(2001) , 10.1172/JCI14452
E.F. Lampeter, M. Homberg, F.A. Gries, H. Kolb, K. Quabeck, U.W. Schaefer, P. Wernet, H. Grosse-Wilde, J. Bertrams, Transfer of insulin-dependent diabetes between HLA-identical siblings by bone marrow transplantation The Lancet. ,vol. 341, pp. 1243- 1244 ,(1993) , 10.1016/0140-6736(93)91148-F
V. Hyttinen, J. Kaprio, L. Kinnunen, M. Koskenvuo, J. Tuomilehto, Genetic Liability of Type 1 Diabetes and the Onset Age Among 22,650 Young Finnish Twin Pairs: A Nationwide Follow-Up Study Diabetes. ,vol. 52, pp. 1052- 1055 ,(2003) , 10.2337/DIABETES.52.4.1052
K. O. Kyvik, L. Nystrom, F. Gorus, M. Songini, J. Oestman, C. Castell, A. Green, E. Guyrus, C. Ionescu-Tirgoviste, P. A. McKinney, D. Michalkova, R. Ostrauskas, N. T. Raymond, The epidemiology of Type 1 diabetes mellitus is not the same in young adults as in children Diabetologia. ,vol. 47, pp. 377- 384 ,(2004) , 10.1007/S00125-004-1331-9
GianFranco Bottazzo, Alejo Florin-Christensen, Deborah Doniach, ISLET-CELL ANTIBODIES IN DIABETES MELLITUS WITH AUTOIMMUNE POLYENDOCRINE DEFICIENCIES The Lancet. ,vol. 304, pp. 1279- 1283 ,(1974) , 10.1016/S0140-6736(74)90140-8