作者: R. David G. Leslie , Lily Ho-Le , Huriya Beyan
DOI: 10.1007/978-1-4614-4051-2_2
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摘要: Autoimmune diseases are the third leading cause of morbidity and mortality in developed world, only surpassed by cancer heart disease. The identification an association between autoimmune disease, type 1 diabetes, certain genes transformed our understanding this disease other related diseases, including thyroid multiple sclerosis. But non-genetic factors also important, chapter tracks these how that knowledge has flowered recent years. In last decade, attention focused on possibility immunomodulation as a secondary or tertiary form prevention diabetes. decline interest destructive immune change potential target therapy switched focus away from autoimmunity back to non-genetic, specifically environmental, events. Given environmental have, indeed, been implicated aetiology prospect is held intervention avoid limit exposure such might eventually reduce incidence of, even eliminate,