Transfer of insulin-dependent diabetes between HLA-identical siblings by bone marrow transplantation
作者： E.F. Lampeter , M. Homberg , F.A. Gries , H. Kolb , K. Quabeck
DOI: 10.1016/0140-6736(93)91148-F
关键词:
摘要: Insulin-dependent diabetes was observed in a woman, aged 29, 4 years after transplantation of bone marrow from her HLA-identical brother with insulin-dependent diabetes. Both had classic symptoms and insulin dependency onset. At diagnosis the recipient positive for high-titre islet cell antibodies (ICA) whereas she been ICA negative before transplantation. Chromosomal analyses verified that all circulating leucocytes were male donor type. These findings suggest transfer by cells confirm immune nature disease.
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