Cytokine-Mediated Enhancement of Epidermal Growth Factor Receptor Expression Provides an Immunological Approach to the Therapy of Pancreatic Cancer

摘要: The increased expression of epidermal growth factor receptor induced by tumor necrosis α renders pancreatic cancer cells more susceptible to antibody-dependent cellular cytotoxicity a mAb specific for this receptor. Laboratory studies with athymic mice bearing xenografts human demonstrated cytokine-induced ability the cause significant regression. In phase I/II clinical trial, 26 patients unresectable were enrolled into three cohorts receiving variable amounts antibody together constant amount α. With increasing doses antibody, primary was significantly inhibited. This reflected longer median survival, one complete remission lasting 3 years obtained highest dose employed. Thus, combination cytokine, α, offers potentially useful approach treatment cancer.