Acute effects of doxazosin and atenolol on smoking-induced peripheral vasoconstriction in hypertensive habitual smokers.

摘要: The acute effects of selective alpha 1 inhibition with doxazosin (0.5-0.7 mg intravenously) and beta 1-blockade atenolol (0.1 mg/kg body weight, on smoking-induced peripheral vasoconstriction were investigated in 24 hypertensive habitual smokers. Forearm blood flow was measured by venous occlusion plethysmography skin estimated thermography laser doppler flowmetry. After the patients had smoked two cigarettes, plasma adrenaline elevations similar under basal conditions after drug administration; noradrenaline remained unchanged. increase heart rate attenuated compared values. systolic pressure more marked (P less than 0.05) before administration. diastolic enhanced but unchanged doxazosin. Smoking increased forearm vascular resistance 0.01) not Similarly, temperature significantly reduced smoking administration 0.001) reduction 0.05). Thus, muscular cutaneous inhibited as opposed to This may reflect unmasked beta-adrenoceptor mediated vasodilation addition 1-adrenoceptor vasoconstriction.