miR-3622a promotes proliferation and invasion of bladder cancer cells by downregulating LASS2
作者： Shi Fu , Ting Luan , Changyi Jiang , Yinglong Huang , Ning Li
DOI: 10.1016/J.GENE.2019.02.083
关键词:
摘要: As a tumor metastasis suppressor gene, LASS2 has been found to be negatively associated with the stage of bladder cancer and overall survival patients. However, mechanisms regulating in remain poorly understood. Here, we aim identify miRNA that targets from cancer-associated miRNAs reveal its potential functions cells. Through microarray bioinformatics analyses, identified miR-3622a as negative regulator LASS2. The expression levels tissues were correlated Overexpression significantly increased proliferation invasion abilities In conclusion, our results indicate promotes cells by downregulating
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Johnny Stiban, Rotem Tidhar, Anthony H. Futerman, Ceramide synthases: roles in cell physiology and signaling. Advances in Experimental Medicine and Biology. ,vol. 688, pp. 60- 71 ,(2010) , 10.1007/978-1-4419-6741-1_4
Shao-hua Fan, Yan-yan Wang, Zhi-yong Wu, Zi-feng Zhang, Jun Lu, Meng-qiu Li, Qun Shan, Dong-mei Wu, Chun-hui Sun, Bin Hu, Yuan-lin Zheng, AGPAT9 suppresses cell growth, invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer Oncotarget. ,vol. 6, pp. 18406- 18417 ,(2015) , 10.18632/ONCOTARGET.4074
QINGHUA ZHAO, HAIFENG WANG, MINGYING YANG, DELIN YANG, YIGANG ZUO, JIANSONG WANG, Expression of a tumor-associated gene, LASS2, in the human bladder carcinoma cell lines BIU-87, T24, EJ and EJ-M3. Experimental and Therapeutic Medicine. ,vol. 5, pp. 942- 946 ,(2013) , 10.3892/ETM.2013.892
Yonghua Han, Jiahao Chen, Xiaokun Zhao, Chaozhao Liang, Yong Wang, Liang Sun, Zhimao Jiang, Zhongfu Zhang, Ruilin Yang, Jing Chen, Zesong Li, Aifa Tang, Xianxin Li, Jiongxian Ye, Zhichen Guan, Yaoting Gui, Zhiming Cai, MicroRNA Expression Signatures of Bladder Cancer Revealed by Deep Sequencing PLOS ONE. ,vol. 6, ,(2011) , 10.1371/JOURNAL.PONE.0018286
Adel H Jebar, Carolyn D Hurst, Darren C Tomlinson, Colin Johnston, Claire F Taylor, Margaret A Knowles, None, FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma Oncogene. ,vol. 24, pp. 5218- 5225 ,(2005) , 10.1038/SJ.ONC.1208705
Hui Pan, Wen-Xin Qin, Ke-Ke Huo, Da-Fang Wan, Yao Yu, Zhi-Gang Xu, Qian-De Hu, Kerong T Gu, Xiao-Mei Zhou, Hui-Qiu Jiang, Ping-Ping Zhang, Yi Huang, Yu-Yang Li, Jian-Ren Gu, None, Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. Genomics. ,vol. 77, pp. 58- 64 ,(2001) , 10.1006/GENO.2001.6614
Tianxin Lin, Wen Dong, Jian Huang, Qiuhui Pan, Xinlan Fan, Caixia Zhang, Li Huang, MicroRNA-143 as a Tumor Suppressor for Bladder Cancer Journal of Urology. ,vol. 181, pp. 1372- 1380 ,(2009) , 10.1016/J.JURO.2008.10.149
Lars Dyrskjøt, Marie S. Ostenfeld, Jesper B. Bramsen, Asli N. Silahtaroglu, Philippe Lamy, Ramshanker Ramanathan, Niels Fristrup, Jens L. Jensen, Claus L. Andersen, Karsten Zieger, Sakari Kauppinen, Benedicte P. Ulhøi, Jørgen Kjems, Michael Borre, Torben F. Ørntoft, Genomic profiling of microRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitro. Cancer Research. ,vol. 69, pp. 4851- 4860 ,(2009) , 10.1158/0008-5472.CAN-08-4043
Margaret A Knowles, None, Molecular pathogenesis of bladder cancer International Journal of Clinical Oncology. ,vol. 13, pp. 287- 297 ,(2008) , 10.1007/S10147-008-0812-0
Daniela Witten, Robert Tibshirani, Sam Gu, Andrew Fire, Weng-Onn Lui, Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls BMC Biology. ,vol. 8, pp. 58- 58 ,(2010) , 10.1186/1741-7007-8-58