Pharmaceuticals in the aquatic environment––a comparison of risk assessment strategies

摘要: The growing concern over the release of pharmaceutically active compounds and personal care products into environment has prompted introduction risk assessment guidelines in both European Union by Medicines Evaluation Agency (EMEA) United States Food Drug Administration (FDA), details which are presented herein. Both employ a similar tiered system that compares predicted environmental concentrations (PEC) with worst-case no effect estimated from standard toxicity assays. These approaches compared contrasted. Results demonstrate room for improvement areas such as use threshold values to trigger investigations, chronic mechanism specific screening mixture possible solutions proposed.